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2) PMID: 20399757
3) Acupuncture inhibits oxidative stress and rotational behavior in 6-hydroxydopamine lesioned rat.
Yu YP, Ju WP, Li ZG, Wang DZ, Wang YC, Xie AM.
Brain research. Volume 1336, 8 June 2010, Pages 58-65
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ÀÌÀü ¿¬±¸¿¡¼ MPTP¸¦ ÀÌ¿ëÇÑ ÆÄŲ½¼ Áúȯ µ¿¹°¸ðµ¨¿¡¼ Àüħ Ä¡·á°¡ »êȽºÆ®·¹½º¸¦ ÁÙ¿©Áشٴ ¿¬±¸°á°ú¸¦ ¹ßÇ¥Çß¾ú´Ù. (The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum-J Physiol Sci (2010) 60:27–34). º» ½ÇÇè ¿¡¼´ÂMPTP·Î À¯¹ßµÈ µ¿¹° ¸ðµ¨¿¡ GB34¿Í GB39¿¡ ÀüħÀ¸·Î ÀÚ±ØÀ» ÇÏ¿© ½ÇÇèÀ» ÁøÇàÇÏ¿´´Ù. ´ëÁ¶±º°ú MPTP±º °£¿¡ 13°³ÀÇ ½Å°æÀü´Þ¹°Áú °ü·Ã ´Ü¹éÁúµéÀÌ Æ¯Â¡ÀÖ°Ô ¹ßÇö µÇ¾ú°í, MPTP¿Í ÀüħÀ» óġÇÑ ±º¿¡¼´Â ´ëÁ¶±º°ú ºñ½ÁÇÏ°Ô cMDH, munc18-1, HAGHÀÇ ¹ßÇöÀ» ¾ïÁ¦ÇÏ°í, COX-5bÀÇ ¹ßÇöÀ» Áõ°¡½ÃÄ×´Ù. ÀÌ´Â ÀüħÀÌ MPTP·Î À¯µµµÈ »êÈ ½ºÆ®·¹½º¿Í ½Å°æ µ¶¼ºÀÇ ¾ïÁ¦¸¦ ÅëÇØ ½Å°æº¸È£¿¡ È¿°úÀûÀÎ °ÍÀ¸·Î ³ªÅ¸³µ´Ù.
º» ¿¬±¸¿¡¼´Â 6-hydroxydopamine rat ¸ðµ¨À» ÀÌ¿ëÇÏ¿© GB34 (Yanglingquan), LR3 (Taichong), ST36 (Zusanli) and SP10 (Xuehai)¿¡ ħ Ä¡·á¸¦ ÇÏ°í reactive oxygen species (ROS)¿Í °ü·ÃÀÌ ÀÖ´Â enzymatic, viz., superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and nonenzymatic, viz., reduced glutathione (GSH), and the levels of malondialdehyde (MDA)µîÀÇ levelsÀ» ÃøÁ¤ÇÏ¿´´Ù. ±× °á°ú ħ Ä¡·á´Â 6-hydroxydopamine lesioned¿¡¼ antioxidative/¶Ç´Â neuroprotective properties¸¦ º¸¿´°í, antioxidant ¹æ¾î systemÀ» Á¶ÀýÇß´Ù.
superoxide dismutase (SOD) - È°¼º »ê¼Ò¸¦ Á¦°ÅÇÏ´Â È¿¼Ò
glutathione peroxidase (GSH-Px) -Á¶Á÷ ÁßÀÇ Áö¹æ»êȽà ¹ß»ýÇÏ´Â °ú»êȼö¼Ò¸¦ ºÐÇØÇϴµ¥ °ü¿©ÇÏ´Â È¿¼Ò
catalase (CAT) - °ú»êȼö¼Ò¸¦ ¹°°ú »ê¼Ò·Î ºÐÇØÇÏ´Â È¿¼Ò
glutathione (GSH) - °ú»êÈÁöÁú(È°¼º»ê¼Ò°¡ ÁöÁú°ú °áÇÕÇÑ °Í)À» ºÐÇØ
malondialdehyde (MDA) - °ú»êÈÁöÁú »êÈÀÇ ÃÖÁ¾»ê¹°
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