> 주 제 : Understanding the molecular and genetic features of prostate cancer by transgenic mice approaches
> 연 사 : 이상현 박사
> 소 속 : Dr. Thomas Roberts’ Lab.
Dana-Farber Cancer Institute Harvard University
> 일 시 : 2006. 08. 14(월요일) p.m 16:00 ~
> 장 소 : 경희대(수원) 전자정보구관 442호 세미나실
> 주 최 : 과학기술부·한국과학재단
> 주 관 : 경희대 침구경락과학연구센터
Prostate cancer is the second death causing cancer in USA. Fundamental molecular mechanisms of the prostate cancer have been poorly understood, which has caused slow progression in developing better therapeutic and prognostic methods. This is mostly due to lack of fundamental understandings of molecular mechanisms and a dearth of proper in vivo animal model systems. Therefore, this work is focused on creating animal models and studying molecular mechanisms in prostate cancer. Here, we induce gene expression of PI3 kinase p110 beta, Polyoma Virus middle T antigen, and luciferase in mouse prostate. Both PI3 kinaseand PyV mT induce mouse PIN. DNA array results display multiple pathway genes are up-/down-regulated. In conclusion, animal models that we have created reflect the characteristic of human prostate cancer and can be used for testing the efficacy of therapeutic drugs.