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2) PMID : 18838174
3) Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain.
Tyagi E, Agrawal R, Nath C, Shukla R.
Journal of Neuroimmunology 2008;Pages 51-56
4) Lipopolysaccharide(LPS)´Â ¸»ÃÊÁ¶Á÷ÀÇ macrophages È°¼ºÀ» ÅëÇؼ ¸é¿ª ½Ã½ºÅÛÀ» ÀÚ±ØÇÑ´Ù. LPS´Â ³ú¾ÈÀÇ microglia, astrocytes È°¼º ½ÃÄÑ interleukin-1¥â (IL-1¥â), tumor necrosis factor-¥á (TNF-¥á)À» ¹æÃâÇÑ´Ù. microglia È°¼ºÀº Alzheimer's and Parkinson's diseases¿Í °°Àº neurodegenerative
diseases·Î ¹ßÀüµÉ ¼ö ÀÖ´Ù°í °üÂûµÈ´Ù. È°¼ºµÈ microgliaÀº inflammatory cytokines ¿äÀÎÀÎ IL-1¥â and TNF-¥á¿Í free radicalsÀÎ »ê¼Ò¿Í Áú¼ÒµîÀ» ¹ß»ý½ÃÄÑ, neurodegenerative°¡ ÁøÇàµÇ´Â °Í¿¡ ±â¿©ÇÑ´Ù.
Rat¿¡°Ô LPSóġ¸¦ Çϸé microglia È°¼ºÀÌ neuronal degeneration¿¡ ±â¿©ÇÏ¿©, Çظ¶ºÎÀ§¿¡ neuronal
function¿¡ ¼Õ»óÀ» ÀÔÈ÷°í, ½ºÆ®·¹½ºÀÇ ¿äÀΰú central neurotransmitter º¯È¸¦ ½ÃŲ´Ù. ±×·¡¼ ¸é¿ª ¼¼Æ÷´Â Cholinergic systemacetylcholine(ACh, mAChR, nAChR, ChAT, AChE)À» ±¸¼ºÇÏ°Ô µÇ´Âµ¥, À̶§ Cholinergic systemÀº ½Å°æ¸é¿ª »óÈ£ÀÛ¿ë°ú ¸é¿ª¹ÝÀÀÀ» ±ÔÁ¤ÇØ ÁÖ´Â Áß°³ÀÚÀÇ ¿ªÇÒÀ» ÇÑ´Ù.
º» ¿¬±¸¿¡¼´Â nonsteroidal anti-inflammatory drugs (NSAIDs)ÀÎ ibuprofenÀ» »ç¿ëÇÏ¿©, neurodegenerative diseasesÀ» ¿¹¹æÇÒ ¼ö ÀÖ´Â È¿°ú¸¦ ã°íÀÚ ÇÏ¿´´Ù. ibuprofen(NSAID)Àº AD mouse model
¿¡¼ º¸È£ÇÏ´Â È¿°ú°¡ ÀÖ¾ú´Ù°í ÇÑ´Ù. LPS I.C.V. injectionÀ¸·Î ¾ß±âµÈ AChEÀÇ È°¼º¿¡¼ ibuprofen
(NSAID) proinflammatory cytokines, AChE È°¼º, »êȽºÆ®·¹½º markers¿¡¼ È¿°ú°¡ ÀÖ¾ú´Ù.
AD ȯÀÚ¿¡¼ AChEÀÇ È°¼º¿¡ ÀÇÇÑ proinflammatory, anti-inflammatory cytokinesÀÎÀÚÀÎ TNF-¥á,
IL-1, IL-6, IL-4µîÀÌ »ý»êµÇ°í, ±×°ÍÀ» º¼ ¼ö°¡ ÀÖ¾ú´Ù. Alzheimer ȯÀڵ鿡°Ô AChEÀ» ¾ïÁ¦ ½ÃÄ×´õ´Ï,
proinflammatory, anti-inflammatory cytokinesÀÌ Á¶ÀýÀÌ µÇ¾ú´Ù. ±×·¯³ª, neuroinflammatoryÀÌ ÁøÇàµÇ´Â°Í¿¡ cholinergic systemÀÌ ¸¹Àº °ü¿©´Â ÇÏÁö ¸øÇÏ¿´´Ù.
º» ¿¬±¸¸¦ ÅëÇؼ, LPS I.C.V. injectionÀ¸·Î ¾ß±âµÈ AChE°¡ È°¼ºÀ¸·Î ÀÎÇÑ neuroinflammation model¿¡¼ °¢°¢ ´Ù¸¥ ºÎÀ§ : striatum(STR), cerebral cortex(CC), hippocampus(HP) and hypothalamus(HT)¿Í °¢°¢ ´Ù¸¥ ½Ã°£ : 4, 12, 24, 48, 96hour¿¡ µû¸¥ ibuprofenÀÇ È¿°ú¸¦ º¸¿©ÁÖ·Á°í ÇÑ´Ù.
5) Åä·Ð : ÀúÀÚÀÇ 2007³â ³í¹®¿¡¼´Â LPS¸¦ I.P. injectionÀ» ÇÏ¿´´Ù. ÇÏÁö¸¸ 2008~2010³â ÃÖ±Ù³í¹®À» º¸°Ô µÇ¸é I.C.V. injectionÀ» ÇÑ°ÍÀ¸·Î º¸¾Æ¼ ºñƯÀÌÀûÀÎ LPS¸¦ Á÷Á¢ ³ú¿¡ Áֻ縦 ÇÏ¿©, È®½ÇÈ÷ À¯¹ßÀ» Çϱâ À§Çؼ°¡ ¾Æ´Ò±î¶ó´Â »ý°¢À» Çغ»´Ù. À¯¹ßÀÌ µÈ ÈÄ, ¿©·¯¾à¹°À» ÅëÇؼ ¿°ÁõÀ» ¾àȽÃÅ°°Å³ª ½Å°æÀ» º¸È£ÇÏ´Â °ÍÀ» º¸¾Ò´Ù.
º» ¿¬±¸ÀÚ´Â ¾ÕÀ¸·ÎÀÇ ½ÇÇè¿¡ ´ëÇؼ ħ°ú neuroinflammatory¿¡ ¿µÇâÀ» Áشٴ ³í¹®µéÀ» ¹ÙÅÁÀ¸·Î, ħÀÌ ¿°ÁõÀ» ³·Ãß°í, ½Å°æº¸È£¸¦ ÇÒ ¼ö ÀÖ´ÂÁö¿¡ ´ëÇÑ ¿¬±¸¸¦ ÇÒ °ÍÀÌ´Ù.
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